Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide [version 1; referees: 3 approved]
Therapeutic medications for the treatment of depression have serious limitations, particularly delayed onset and low rates of efficacy.However, the discovery that a Wooden Figure single subanesthetic dose of ketamine, a glutamate NMDA receptor channel blocker, can produce a rapid (within hours) antidepressant response that is sustained (about 1 wee