KETAMINE AND RAPID-ACTING ANTIDEPRESSANTS: A NEW ERA IN THE BATTLE AGAINST DEPRESSION AND SUICIDE [VERSION 1; REFEREES: 3 APPROVED]

Ketamine and rapid-acting antidepressants: a new era in the battle against depression and suicide [version 1; referees: 3 approved]

Therapeutic medications for the treatment of depression have serious limitations, particularly delayed onset and low rates of efficacy.However, the discovery that a Wooden Figure single subanesthetic dose of ketamine, a glutamate NMDA receptor channel blocker, can produce a rapid (within hours) antidepressant response that is sustained (about 1 wee

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